Adding a certain compound to certain chemical reactions, such as: 19225-92-4, name is 2-(Chloromethyl)-1-methyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19225-92-4, Recommanded Product: 2-(Chloromethyl)-1-methyl-1H-imidazole
[1-[3-(1-Methyl-1H-imidazol-2-ylmethoxymethyl)-phenyl]-1 H-imidazole-4- carboxylic acid ethyl ester] (14a)To a suspension of NaH (308 mg, 7.7 mmol, 60% in mineral oil) in dry THF (6 ml_) under N2 atmosphere was added a solution of alcohol 7 (410 mg, 1.38 mmol) in THF (2 ml_) while stirring for 30 min at room temperature. The reaction mixture was cooled to O0C and the compound 14 (crude 200 mg, 1.53 mmol) in THF (1 ml_) was added dropwise and allowed to come to room temperature during a period of 30 min after which it was refluxed for 12 h. The mixture was quenched with ice water (5 ml_), acidified to pH 2-3 by adding aqueous HCI solution (2N). The reaction mixture was extracted with CH2CI2 (3 x 20 ml_), washed with brine, dried over Na2SO4 and concentrated. The crude mass was taken in ethanol (10 ml_), purged HCI gas for 30 min. and stirred at room temperature for 3 h. After evaporation of solvent, the crude mass was purified by column chromatography using 28% ethylacetate in hexane to furnish 14a (150 mg, 25%) as a white solid, mp-83.8-88.6C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Chloromethyl)-1-methyl-1H-imidazole, and friends who are interested can also refer to it.
Reference:
Patent; NEUROSEARCH A/S; WO2007/42545; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem