In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 312-73-2 as follows. COA of Formula: C8H5F3N2
General procedure: In a typical experimental procedure, a dry, two-necked, 50 mL round bottomed flask was charged with 5 mL of dry MeCN, 1.0 mmol of benzimidazole derivatives and 1.0 mmol of NaH. The solution was stirred at room temperature for 30 min, then a solution of 2,2,2-trifluoro acetimidoyl chloride derivatives (1.0 mmol in 2 mL of dry MeCN) was added dropwise via a syringe. The mixture was stirred at room temperature appropriate time and then filtered. After removing the solvent under reduced pressure, the crude product was purified by preparative thin-layer chromatography on silica gel [eluent: n-hexane/EtOAC, 3:1] to give the products. The products obtained from 2-mercapto benzimidazole and 2-mercapto-1-methyl imidazole were purified by washing with n-hexane.
According to the analysis of related databases, 312-73-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Darehkordi, Ali; Rahmani, Fariba; Journal of Fluorine Chemistry; vol. 190; (2016); p. 41 – 47;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem