Related Products of 17289-26-8,Some common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A sealed tube is charged with tert-butyl 4-(p-tolylsulfonylhydrazono)- piperidine-1-carboxylate (1284.79 mg; 3.50 mmol; 1 .10 eq.), CS2CO3 (1553.44 mg; 4.77 mmol; 1 .50 eq.). The tube is RM is sealed, purged with argone and then 1 ,4-dioxane (12.00 mL) and 1 -methyl-1 – -imidazole-4- carbaldehyde (350.00 mg; 3.18 mmol; 1.00 eqf.) are added. RM is heated at 1 10C for 48 h. After this time, the mixture is filtered through a Celite pad and then the solvent is evaporated. Crude product is purified by FCC (hexane/EtOAc; gradient) to afford 4-(1 -methyl-1 H-imidazole-4-carbonyl)- piperidine-1 -carboxylic acid tert-butyl ester (483.90 mg; yield 51.0 %; 98% by UPLC) as a beige solid
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-4-carbaldehyde, its application will become more common.
Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem