Introduction of a new synthetic route about 116343-89-6

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 116343-89-6.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 116343-89-6, name is Methyl 1-phenyl-1H-imidazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 1-phenyl-1H-imidazole-4-carboxylate

Step 3 Synthesis of 1-Phenyl-1H-imidazole-4-carboxylic acid To a stirred solution of 1-phenyl-1H-imidazole-4-carboxylic acid methyl ester (200 mg, 0.98 mmol) in a mixture of THF (3 mL), MeOH (3 mL), H2O (2 mL) was added, LiOH.H2O (249 mg, 5.9 mmol) and stirring was continued at ambient temperature for 2 hr. The reaction mixture was concentrated under reduced pressure. Cold water was then added to the residue which was then acidified with 10% aqueous HCl. The product was extracted with ethyl acetate. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford 105 mg (56%) of 1-phenyl-1H-imidazole-4-carboxylic acid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 116343-89-6.

Reference:
Patent; Bischoff, Alexander; Subramanya, Hosahalli; Sundaresan, Kumar; Sammeta, Srinivasa Raju; Vaka, Anil Kumar; US2010/160323; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem