Electric Literature of 583-39-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 583-39-1 as follows.
Sodium hydroxide (1.60 g, 40 mmol) was dissolved in 2-PrOH (70 ml), benzimidazole-2-thione 1 (6.00 g, 40 mmol) was added followed by portionwise addition of chloroacetamide (3.75 g, 40 mmol). The reaction mixture was refluxed for 3 h, cooled, the precipitate was filtered off, washed with water, and dried. Yield 6.75 g (81%), colorless crystals
According to the analysis of related databases, 583-39-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Bespalov; Gorchakova; Ivanov; Kuznetsov; Kuznetsova; Pankova; Prokopenko; Avdontceva; Chemistry of Heterocyclic Compounds; vol. 50; 11; (2015); p. 1547 – 1558;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem