Electric Literature of 641571-11-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Dimethyl sulfoxide (10 mE), 3-(4-methyl-1H-imi- dazole-1 -yl)-5-(trifluoromethyl) aniline (aromatic amine, 4.5 mmol), N-5-bromo-2-methylphenyl(4-(pyridine-3-yl) pyrimidine-2-amine (5.4 mmol), 1, 1?-bis(diphenylphos- phino)ferrocene-palladium (II) dichloride dichioromethane complex (0.135 mmol), triphenylphosphine (0.27 mmol), phenol (0.225 mmol), triethylamine (13.5 mmol) and a 4 A molecular sieve (1 g) are added into an autoclave for uniform stirring. Nitrogen is introduced to displace air, and then a carbon monoxide is introduced to displace the nitrogen to and the pressure in the autoclave is increased to 0.8 MPa. A temperature is increased by heating to 90-105 C. for reaction. Afier 72 h reaction, a product system containing an amination product is obtained. The product system is cooled to be below 50 C., and the carbon monoxide is evacuated and displaced with the nitrogen.
The synthetic route of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASYMCHEM LABORATORIES (TIANJIN) CO., LTD; ASYMCHEM LIFE SCIENCE (TIANJIN) CO., LTD; TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD; ASYMCHEM LABORATORIES (FUXIN) CO., LTD; JILIN ASYMCHEM LABORATORIES CO., LTD; HONG, Hao; JAMES, Gage; LI, Jiuyuan; LI, Changfeng; HUANG, Gaochao; (16 pag.)US2018/148430; (2018); A1;,
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