In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51605-32-4, name is Ethyl 5-methyl-1H-imidazole-4-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 51605-32-4
N-Amination of ethyl 5-methyl-3H-imidazole-4-carboxylic acid (5.39 g, 34.96 mmol) following the general procedure. Purification by flash chromatography on silica gel eluting with 0% increasing to 4% methanol in dichloromethane gave a yellow-white solid (4.23 g, 71%). Rf 0.53 (7% MeOH in DCM), 1H NMR (300 MHz, CDCl3): delta 7.48 (s, 1H), 5.33 (s, 2H), 4.27 (q, J=6.9 Hz, 2H), 2.35 (s, 3H), 1.31 (t, J=6.9 Hz, 3H). 13C NMR (75 MHz, CDCl3): delta 61.9 (CO2Et), 146.6, 140.4 (CH), 118.4, 60.8, 16.4, 14.7. MS, m/z (%) 170 (100) [M++1] Anal. Calcd for C7H11N3O2 (169.18): C, 49.70; H, 6.55; N, 24.84. Found: C 49.85, H 6.45, N 24.74.
The synthetic route of 51605-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Heim-Riether, Alexander; Rotella, David Paul; US2006/264624; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem