Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1003-21-0, name is 5-Bromo-1-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Computed Properties of C4H5BrN2
Example No. 18: Preparation of Compound No. 18[0306] A solution of 2,8-dimethyl-2,3,4,5-tetrahydro- lH-pyrido[4,3-b]indole (0.4 g, 2 mmol), 5-bromo-l-methyl-lH-imidazole (0.644 g, 4 mmol), K3P04 (0.848 g, 4 mmol), Cul (38 mg, 0.2 mmol) and L-Proline (46 mg, 0.39 mmol) in dry DMF (6 mL) was stirred at 150 C for 16h. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude material, which was purified by reverse phase HPLC to yield 2,8-dimethyl-5-(3-methyl-3H- imidazol-4-yl)-2,3,4,5-tetrahydro-lH-pyrido[4,3-b]indole (15 mg). 1H NMR (HC1 salt, CD3OD) delta (ppm): 9.20 (s, IH), 8.0 (s, IH), 7.40 (s, IH), 7.20 (d, IH), 7.10 (d, IH), 4.76 (d, IH), 4.40 (d, . n . m, H , . , H , . s, H , . m, z s, 3H).
The synthetic route of 1003-21-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; PROTTER, Andrew, Asher; CHAKRAVARTY, Sarvajit; WO2012/112962; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem