Synthetic Route of 36947-68-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 36947-68-9 name is 2-Isopropyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of Example 29b (1.3 g, 6.8 mmol), 2-isopropyl-lH-imidazole (0.9 g, 8.2 mmol), CuBr (0.14g, 1.0 mmol), L-proline (0.12g, l .Ommol) and Cs2C03 (4.3 g, 13.6 mmol) was stirred in 40 mL toluene under reflux with the protection of nitrogen for 16 hrs. The solvent was then removed under vacuum, the residue was then washed by water (35 mL), extracted with EtOAc (55 mL) twice, the organic phase was combined, washed with brine, dried over Na2S04, and concentrated under vacuum to give brown oil, which was further purified by combined-flash (EA / PE =70%-95%) to give the desired product Example 29c (120 mg, yield 9%) as yellow solid. LCMS [M+1]+=220.1
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Isopropyl-1H-imidazole, and friends who are interested can also refer to it.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (212 pag.)WO2017/218960; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem