Electric Literature of 124750-92-1, These common heterocyclic compound, 124750-92-1, name is Losartan carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B: 2-butyl-4-chloro-l-{[2′-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-lH-imidazole-5- carboxylic acid To a solution of E3174 (234.58 g, 0.54 mol) in DCM (4500 niL) was added triethylamine (85 niL, 0.59 mol) followed by a solution of trityl chloride (159 g, 0.56 mol) in DCM (800 mL) and the reaction mixture was stirred at rt overnight. The reaction mixture was washed with water, dried (MgSO4), filtered, and concentrated under reduced pressure. Chromatography over silica gel eluting with acetone/heptane 20:80% afforded the title compound as an orange solid.
The synthetic route of 124750-92-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NICOX S.A.; WO2009/150007; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem