Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Amino-1H-benzo[d]imidazol-2(3H)-one
To a solution of 4-tert-butylbenzylamine (2 mL, 1 1.36 mmol) in THF (30 mL) was added CDI (2.1 mol eq, 3.86g) and the mixture was heated at 70C overnight. The reaction mixture was evaporated, water was added and the aqueous phase was extracted with EtOAc (3×30 mL). The recombined organic phases were anhydrified over Na2SO4 and evaporated at reduced pressure (pale yellow oil, quantitative yield). The oil obtained (1.6g, 6.2 mmol)) was dissolved in DMF (25mL) and the bicyclic amine la was added (0.8 mol eq, 0.74g), then the mixture obtained was heated at 100C overnight. The solvent was removed at reduced pressure and the residue was purified by crystallization from MeOH to obtain the product as a white solid (0.54g, 1.59 mmol, 26% Yield).1HNMR (DMSO, 400 MHz) delta 1.26 (s, 9H), 4.28 (d, 2H, J=6), 6.34 (dd, 1H), 6.36 (t, 1H), 6.83-6.91 (m, 2H), 7.26 (d, 2H, J=8), 7.37 (d, 2H, J=8), 8.20 (s, 1H9, 9.89 (bs, 1H), 10.61 (bs, 1H). [M+1] 338.82 (C19H22N4O2 requires 338.40).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem