Application of 1467-16-9,Some common heterocyclic compound, 1467-16-9, name is 1H-Imidazole hydrochloride, molecular formula is C3H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
K2CO3 (3.99 g, 28.8 mmol) and imidazole hydrochloride (1.00 g, 9.60mmol) were dissolved in MeCN (30 mL) in a round-bottomed flask. Benzyl bromide (1.25 mL, 10.6 mmol) was added dropwise to the stirred solution at r.t. After 70 h, the solution was concentrated and the materials redissolved in CH2Cl2 (i.e., CH2Cl2) and then extracted with H2O (3 × 30 mL). The organic layer was then dried (MgSO4). The product was collected as off-white coloured wax (0.63 g, 42% yield). 1H NMR spectrum is consistent with that previously reported.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole hydrochloride, its application will become more common.
Reference:
Article; Herasymchuk, Khrystyna; Huynh, Jennifer; Lough, Alan J.; Roces Fernandez, Laura; Gossage, Robert A.; Synthesis; vol. 48; 13; (2016); p. 2121 – 2129;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem