Synthetic Route of 29043-48-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29043-48-9, name is 2-Methyl-1H-benzoimidazol-5-ylamine, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: First, a mixture of 4-nitrobenzene-1,2-diamine (1 g) and formic acid (0.74 mL) in 5 N HCl (70 mL) was stirred and heated to reflux for 24 h. The mixture was cooled to room temperature and neutralized by 10% NaOH, and precipitate was isolated, recrystallised from water and dried to produce 5-nitrobenzoimidazole (0.69 g) [37]. Next, 5-nitrobenzoimidazole (0.25 g) was dissolved in ethanol (20 mL). The solution was stirred and heated to reflux, and the palladium-on-charcoal catalyst (0.15 g) and hydrazine hydrate (1.6 mL) were added. Then the mixture was stirred for 4 h, and filtered in hot. The filtrate was evaporated, and the residue was recrystallised from ethanol to give rise to the precursor compound 5-aminobenzoimidazole (0.163 g). Finally, a mixture of 4-chloro-6,7-dimethoxyquinazoline hydrochloride (0.25 g), 5-aminobenzoimidazole (0.15 g) in isopropanol (25 mL) was stirred and heated to reflux for 4 h. The precipitate was filtered off, recrystallised from methanol and dried to afford 12 as yellow powder (0.32 g, yield 73%).
The chemical industry reduces the impact on the environment during synthesis 2-Methyl-1H-benzoimidazol-5-ylamine. I believe this compound will play a more active role in future production and life.
Reference:
Article; Lue, Shuang; Zheng, Wei; Ji, Liyun; Luo, Qun; Hao, Xiang; Li, Xianchan; Wang, Fuyi; European Journal of Medicinal Chemistry; vol. 61; (2013); p. 84 – 94;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem