Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16681-59-7, name is 2-Bromo-1-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Safety of 2-Bromo-1-methyl-1H-imidazole
A solution of 1 mmol (0.167 g) of carbazole, 2 mmol (0.322 g) of 2-bromo-N-methyl-imidazole, benzotriazole 40 mol% (0.046 g) 20 mmol% (0.038 g) of copper iodide and 1.4 mmol (0.157 g) of potassium tertiary-butoxide were stirred in 6 mL of dimethylsulfoxide at 135C for 48 hours. The reaction mixture was allowed to cool and then water was added and extracted with ethyl acetate. The ethyl acetate extract was dried over magnesium sulfate and then distilled under reduced pressure. The resulting brown solid was purified by silica column chromatography (using ethyl acetate and hexane). Finally, a colorless solid ligand 12 was obtained. The yield of the ligand 12 was 40%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Samsung Electronics Co., Ltd.; Samsung SD I Co., Ltd.; Das, Rupa Sri Rajini; Lee, Gang Mun; Noh, Chang Ho; Bae, Hay Jin; Rai, Birendra Kumar; Kravtsuk, Dmitry; (49 pag.)KR2016/12890; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem