Adding a certain compound to certain chemical reactions, such as: 10040-98-9, name is 4-Imidazol-1-yl-benzaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10040-98-9, SDS of cas: 10040-98-9
A mixture of malonitrile (30.0 mg, 0.45 mmol) and 4-(1H-imidazol-1- yl)benzaldehyde (78.0 mg, 0.45 mmol) in anhydrous ethanol ( 4.0 mL) was charged with N- methylmorpholine (0.05 mL, 0.45 mmol) for 2 minutes. To the mixture was added 1-(4- fluorophenyl)-3-methyl-1H-pyrazol-5(4H)-one (90.0 mg, 0.45 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 48 hrs. The suspension was filtered under vacuum and off white solid was obtained. The solid was gently washed with hexanes (20 mL) and chilled ethanol (10 mL) and further dried under high vacuum to provide compound 44 as an off white solid (170 mg, 88%).1H NMR (400 MHz, DMSO-d6) delta (ppm): 8.25 (s, 1H), 7.83-7.74 (m, 3H), 7.62 (d, J = 8.4 Hz, 2H), 7.40 (d, J = 8.4 Hz, 2H), 7.36-7.26 (m, 4H), 7.10 (s, 1H), 4.77 (s, 1H), 1.82 (s, 3H). MS (ESI): Calcd for C23H17FN6O: 412, found: 413 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Imidazol-1-yl-benzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; YU, Chengzhi; POLAT, Tulay; YAN, Chao; RABIZADEH, Shahrooz; THEODORESCU, Daniel; (108 pag.)WO2016/205460; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem