Electric Literature of 760212-58-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 760212-58-6 name is 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
SYNTHESIS EXAMPLE 1 (Synthesis of Compound 1); Into a 100-mL three-necked flask, 3.0 g (8.6 mmol) of 1-(4-bromophenyl)-2-phenyl-1H-benzimidazole, 2.2 g (8.7 mmol) of bis(pinacolato)diboronic acid, 0.21 g (0.29 mmol) of [1,1′-bis(diphenylphosphino)ferrocene] dichloropalladium (II), 2.5 g (25 mmol) of potassium acetate, and 50 ml of DMF were charged and the mixture was heated at 80 C for 3 h in argon flow. After confirming the disappearance of the starting boron compound, the mixture was cooled to room temperature. After adding 2.2 g (8.6 mmol) of 9-bromophenanthrene, 0.21 g (0.29 mmol) of [1,1′-bis(diphenylphosphino)ferrocene] dichloropalladium (II), and 21 mL of a 2 M aqueous solution of sodium carbonate, the mixture was further heated at 80 C for 3 h under stirring. After the reaction, water was added. The precipitated crystals were corrected by filtration, washed with water and methanol, and dried under reduced pressure, to obtain a crude reaction product, which was then purified by a column chromatography (silica gel, dichloromethane: hexane), to obtain 2.5 g of white crystals. The obtained crystals were identified to Compound 1 by FD-MS (field desorption mass spectrometry). Yield: 65%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole, and friends who are interested can also refer to it.
Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2236501; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem