The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.
Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10111-08-7, name is Imidazole-2-carboxaldehyde, A new synthetic method of this compound is introduced below., COA of Formula: C4H4N2O
A reaction mixture with 3-amino-lH-pyrrole-2-carboxylic acid ethyl ester (0.2 g, 1.30 mmol), 2-imidazolecarboxaldehyde (0.15 g, 1.53 mmol), NaCNBH3 (0.082 g, 1.30 mmol) EPO and OHAc (0.15 mL, 2.60 mmol) in methanol (5 mL) was stirred at r.t. for 2 h. The solvent was evaporated in vacuo and the residue was dissolved in ethyl acetate. Washed with water and the aqueous layer was extracted twice with ethyl acetate. The combined organic layers were dried (MgSO4), filtered and concentrated. The crude product was purified by flash column chromatography (CH2Cl2/methanol gradient; 0 to 20% methanol), obtaining 0.30 g (99%) of the title compound.1H NMR (DMSO-d6) delta ppm 10.84 (IH, br s), 7.03 (2H, s), 6.79 – 6.64 (IH, m), 5.76 (IH, br s), 5.68 – 5.57 (IH, m), 4.29 (2H, d, J=5.8 Hz), 4.19 (2H, q, J=7.1 Hz), 3.16 (IH, s), 1.26 (3H, t, J=7.1 Hz); MS (ESI) m/z 235 (M +1).
The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2006/62465; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem