10111-08-7, name is Imidazole-2-carboxaldehyde, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of Imidazole-2-carboxaldehyde
To a suspension of NaH (60% in mineral oil, 1.45 g, 36.2 mmol) in DMF (30 mL) was added 2-imidazolecarboxaldehyde (3.00 g, 30.3 mmol) portionwise, and the mixture was stirred at RT for 1 h, then treated with 2-(trimethylsilyl)ethoxymethyl chloride (5.91 mL, 33.3 mmol). The mixture was stirred at RT overnight, then treated with sat. aq. NH4C1 and extracted with EtOAc (3 X 45 mL). The combined organic layers were washed with sat. aq. NaC1 (6 X 30 mL), dried over Na2 SO4, and concentrated under reduced pressure. The residue was purified by Si02 gel chromatography (0/o to 25% EtOAc in CH2C12) to give the title compound as a colorless oil (2.18 g, 32%). ?HNMR (400 MHz. CDC13) oe 9.86 (s, 1H), 7.39 (s, 1H), 7.36 (s, 1H), 5.80 (s, 2H), 3.66-3.47 (m, 2H), 0.98-0.90 (m, 2H), 0.01 (s, 9H).
The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM; SOTH, Michael, J.; JONES, Philip; RAY, James; LIU, Gang; LE, Kang; CROSS, Jason; (141 pag.)WO2018/44808; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem