Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5465-29-2, name is 2-Propylbenzimidazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Propylbenzimidazole
Step A: 2-Propyl-1-(4-(2–t-butoxycarbonylbenzoyl)phenyl)methylbenzimidazole To a suspension of NaH (0.013 mg) in dry DMF (3 ml), 2-propyl benzimidazole (0.052 g, 0.325 mmol) was added, and the mixture was stirred at room temperature for 30 minutes to give a clear solution. To the solution was added t-butyl-2-[4–(bromomethyl)benzoyl]benzoate (0.125 g, 0.33 mmol) [prepared according to the procedure described in European Patent Application 0,253,310]. The mixture, after stirring at room temperature for 3 hours, was poured into ice-water (50 ml) and extracted with ethyl acetate (3 x 20 ml). The combined organic phase was washed with brine, then dried (MgSO4), and evaporated. The crude product was then purified by flash chromatography on silica-gel using ethyl acetate-hexane (1:6). Yield 0.12 g (81%, as amorphous solid). NMR(CDCl3): delta 1.0 (t, J=7Hz, 3H), 1.26 (s, 9H), 1.88 (m, 2H), 2.86 (t, J=7Hz, 2H), 5.4 (s, 2H), 7.05-7.8 (m, 12H); FAB-MS: m/e 455 (M+H).
The synthetic route of 5465-29-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck & Co., Inc.; EP400835; (1990); A1;,
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