Electric Literature of 714273-83-3, These common heterocyclic compound, 714273-83-3, name is 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5 g (32.85 mmol) of 5-(tert-butyl)-1H-imidazole-4-carbaldehyde was added to 35 mL of DMF,An additional 13.02 g (65.7 mmol) of N,N’-diacetylpiperazine-2,5-dione nitrogen was added to protect the exhaust, and 16.05 g (49.28 mmol) of cesium carbonate was added to protect the exhaustThe reaction was stirred at room temperature in the dark for 20 h. The reaction solution was poured into 500 mL of ice water and suction filtered.The filter cake was washed with water (100 mL * 2), petroleum ether: ethyl acetate = 8: 1 (400 mL),The filter cake was dispersed ultrasonically with ethanol and dichloromethane, insoluble matter was filtered off, and concentrated under reduced pressure.Anhydrous ethanol with water. It was further slurried with ethyl acetate (200 mL) to obtain a brown-yellow solid. Get 4.05 g of (Z)-1-acetyl-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione, Yield: 42%.
The synthetic route of 714273-83-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tsingtao Ocean Bio-pharmaceutical Institute Co., Ltd.; Li Wenbao; Fu Zhangyu; Hou Yingwei; Ji Cunpeng; Wang Shixiao; Ma Mingxu; Guan Huashi; (21 pag.)CN110240592; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem