Electric Literature of 870837-18-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 870837-18-6 name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Synthesis of (Z)-(6S*,9aR*)-6-(4-fluorophenyl)-3-[1-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]hexahydropyrido[2,1-c][1,4]oxazin-4-one Triethylamine (0.03 mL) was added to a solution of [(6R*,9aS*)-6-(4-fluorophenyl)-4-oxooctahydropyrido[2,1-c][1,4]oxazin-3-yl]triphenylphosphonium bromide (57 mg) and 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (21 mg) in ethanol (5 mL), and the reaction solution was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure. Then, the residue was purified by silica gel column chromatography (carrier: Chromatorex NH; elution solvent: heptane:ethyl acetate=1:1->ethyl acetate) to obtain 27 mg of the title compound. The property values of the compound are as follows. 1H-NMR (CDCl3) delta (ppm): 1.40-1.58(m,2H), 1.65-1.76(m,2H), 2.18-2.25(m,2H), 2.31(s,3H), 3.85(s,3H), 4.07(q,J=10.8 Hz,1H), 4.07-4.15(m,1H), 4.34(dd,J=10.8,2.4 Hz,1H), 5.38(t,J=4.0 Hz,1H), 6.82(s,1H), 6.92(brs,1H), 7.02(t, J=8.4 Hz,2H), 7.20(d,J=8.0 Hz,1H), 7.22(dd,J=8.0,3.6 Hz,2H), 7.37(dd,J=8.0,1.2 Hz,1H), 7.39(d,J=1.2 Hz,1H), 7.74(d,J=1.2 Hz,1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/117798; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem