In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 641571-13-3 as follows. Computed Properties of C12H9F3N2O2
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid (10 mg, 0.030 mmol), 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (22 mg, 0.058 mmol), and TEA (7.9 mg, 0.078 mmol) were dissolved in DMF (0.2 ml), the solution was stirred at 45 C. for 30 minutes, and then the compound F (10 mg, 0.030 mmol) was added, followed by stirring the solution at 45 C. for 12 hours. After the reaction was completed, ethyl acetate was added, and the reaction mixture was washed with a saturated aqueous NaCl solution. The organic layer was dried with sodium sulfate anhydrous and filtered, and then the solvent was removed under reduced pressure. The residue was crystallized to obtain a target compound 3-(4-methyl-1H-imidazol-1-yl)-N-(4-(2-oxo-2,3-dihydro-1H-thieno[3,4-b][1,4]diazepine-4-yl)phenyl)-5-(trifluoromethyl)benzamide (10.3 mg, 67%). 1H NMR (400 MHz, DMSO-d6) delta 10.77 (1H, s), 10.53 (1H, s), 8.49 (1H, s), 8.43 (1H, s), 8.27 (1H, s), 8.19 (1H, s), 8.09 (2H, d, J=8.8 Hz), 7.95 (2H, d, J=8.8 Hz), 7.75 (1H, s), 7.52 (1H, d, J=4.0 Hz), 7.02 (1H, d, J=3.6 Hz), 3.61 (2H, s), 2.19 (3H, s) (Exact mass 509.11, m/z 510.1193)
According to the analysis of related databases, 641571-13-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Industry-University Cooperation Foundation Hanyang University ERICA Campus; HAH, Jung-Mi; LEE, Jung Hun; KIM, Minjung; (30 pag.)US2018/37589; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem