Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 33468-69-8
Referring to Reaction Scheme 14, Stage 1, a solution of 4-chloro-6-(3,4- dichloro-phenyl)-pyrimidine (1eq), 4-(trifluoromethyl)-1H-imidazole (2eq) and potassium carbonate (1.1eq) in fert-butanol (10vol) was heated at 150C in a microwave for 25 minutes. Potassium carbonate (1.1eq) was added to the reaction mixture, which was heated at 160C in a microwave for 35 minutes. Water was added and the desired material was extracted with EtOAc. The organic phase was dried with MgSO4, filtered and evaporated to dryness. Purification by flash column chromatography (eluent: [99.5:0.5] DCM:MeOH) afforded the target compound.
According to the analysis of related databases, 33468-69-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DOMINGUEZ, Celia; TOLEDO-SHERMAN, Leticia, M.; COURTNEY, Stephen, Martin; PRIME, Michael; MITCHELL, William; BROWN, Christopher, John; DE AGUIAR PENA, Paula, C.; JOHNSON, Peter; WO2013/16488; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem