In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36947-68-9 as follows. name: 2-Isopropyl-1H-imidazole
To a slightly yellow homogeneous solution of 2-isopropylimidazole (10.000 g; 90.778 mmol) in dioxane (155 ml) and distilled water (155 ml) was added successively, at rt (in one portion), sodium carbonate (28.865 g; 272.333 mmol), and iodine (50.688 g; 199.711 mmol). The resulting brown heterogeneous reaction mixture was further stirred at rt, under nitrogen, for 24h. EA (450 ml) was then added followed by an aq. solution of sodium thiosulfate (27 g Na2S2O3 in 270 ml of water). The yellow homogeneous organic layer was separated and additionally washed with an aq. solution of sodium thiosulfate (18 g Na2S2O3 in 180 ml of water), and finally with brine (130 ml). The yellow organic layer was then dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure to give the pure product 4, 5-diiodo-2-isopropyl-1 /-/-imidazole as a yellow solid which was further dried under HV (31.810 g; 97%). LC-MS: tR = 0.62 min.; [M+H]+ = 363.19 g/mol.
According to the analysis of related databases, 36947-68-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/78291; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem