Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16042-25-4, name is 2-Imidazolecarboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 16042-25-4
HATU (0.16 g, 0.43 mmol) was added to a solution of 3-chloro-5-({6-chloro-2-fluoro- 3-[(methylamino)methyl]phenyl}oxy)benzonitrile (0.10 g, 0.30 mmol) and 1 H- imidazole-2-carboxylic acid (0.05 g, 0.43 mmol) in DMF (3 ml.) and the solution was stirred at RT overnight. After 16 h, ethyl acetate (100 ml) and saturated NaHCOs solution (100 ml) were added. The organic layer was separated, washed with saturated NaHCOs solution (2 x 100 ml), brine (150 ml_), dried over MgSO4, filtered and concentrated. The crude material was purified by Reverse Phase HPLC to give the title compound (0.025 g, 20%) as a white solid. 1H NMR (400 MHz, DMSO-c/6) delta ppm 7.82 (s, 1 H), 7.46 – 7.57 (m, 3 H), 7.27 – 7.37 (m, 2 H), 7.18 (s, 1 H), 5.57 (s, 1 H), 4.77 (s, 1 H), 3.53 (s, 1.5 H), 2.98 (s, 1.5 H). 19F NMR (376 MHz, DMSOd6) delta ppm -75.19 (s, 1 F). LCMS m/z 418 (M-1 ).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/154271; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem