Electric Literature of 53710-78-4, These common heterocyclic compound, 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Necked flask was added 100mg (0.24mmol) compound 3a and 10mL anhydrous DMF,Was added 9.6mg (0.24mmol) 60% NaH was dissolved with stirring,Stirred at room temperature 30min,Was then added 52mg (0.36mmol) 1- (3- chloropropyl) lH-imidazole,The reaction temperature was raised to 80 5H, the reaction was complete, the reaction was poured into 200mL of water,Extracted with ethyl acetate (50mL × 3), the combined organic layers washed with brine (150mL × 3), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (dichloromethane: methanol: triethylamine = 120: 4: 1, v / v / v) to afford 64.4mg 3i red solid, yield 51.0%
The synthetic route of 53710-78-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University; Shanghai Institute of Materia Medica; Ye, Qing; Li, Jia; Zhou, Yubo; Gao, Anhui; Gao, Lixin; Hu, Yuanyuan; Li, Xue; Gao, Jianrong; (17 pag.)CN105777751; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem