Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50995-95-4, name is 2-Propylimidazole, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives
STAGE 1: 1-((6-chloro 1,3-benzodioxol-5-yl)methyl)-2-n-propyl1H-imidazole 12 g of 2-n-propyl-1H-imidazole is introduced into 125 ml of anhydrous dimethylformamide, 5.28 g of sodium hydride at 50% in oil is added slowly in fractions, agitation is carried out for 20 minutes then 22.55 g of 6-chloro-piperonyl chloride is added in fractions and agitation is continued for one hour at ambient temperature. The dimethylformamide is evaporated off with a rotary evaporator then the residue is acidified then hydrolyzed using saturated ammonium chloride. Extraction is carried out 3 times with methylene chloride. The organic phase is washed with distilled water, dried, then impasted in ethyl ether and dried. In this way 22.2 g of expected product (white powder) is obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Hoechst Marion Roussel; US5986103; (1999); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem