These common heterocyclic compound, 714273-83-3, name is 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde
1 g (6.5 mmol) of 5- (tert-butyl) -1H-imidazole-4-carbaldehyde was added to 7 mL of DMF,An additional 2.59 g (13 mmol)N, N-diacetylpiperazine-2,5-dione nitrogen protection row of the third gas,3.19 g (9.8 mmol) of cesium carbonate,Nitrogen gas to protect the row of gas,The reaction was stirred at room temperature for 20 h without light.The reaction was poured into ice-water (100 mL) and suction filtered. The filter cake was washed with water (100 mL * 2), then with petroleum ether: ethyl acetate 8: 1 (90 mL). The filter cake was washed with ethanol and dichloromethane Ultrasound pointsScattered, filtered to remove insoluble material, concentrated under reduced pressure, anhydrous ethanol with water. Beating with ethyl acetate (50 mL) afforded a tan solid(Z) -1 -acetyl-3 – ((5- (tert-butyl) -1H-imidazol-4-yl) methylene) piperazine-2,5-dione 0.89 g, yield 46.9%.
The synthetic route of 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tsingtao Ocean Bio-pharmaceutical Institute Co., Ltd.; Li Wenbao; Ding Zhongpeng; Wang Shixiao; Sun Tianwen; Hou Yingwei; Guan Huashi; (14 pag.)CN107011322; (2017); A;,
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