Reference of 66121-69-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 66121-69-5 as follows.
After dissolving 1-methylimidazole-4-carbonitrile (1.0 g, 8.0 mmol) in DMF (30 mL), trifluoroacetic hydrazide (1.9 g, 14.8 mmol)After adding and stirring at room temperature for 30 minutes.After adding sodium methoxide (28% methanol solution) to the reaction mixture, the mixture was raised to 140 C and stirred with heating for 48 hours.The reaction mixture was cooled to room temperature, the solvent was blown out, and then extracted with ethyl acetate and water. The organic layers are collected, dehydrated with sodium sulfate, the solids are filtered off and the solvent is blown off. The reaction mixture was purified using silica gel column chromatography to obtain compound (4).(0.35 g, 1.6 mmol) is obtained with a yield of 20%.
According to the analysis of related databases, 66121-69-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Samsung Electronics Co., Ltd.; Cheil Industries Inc.; Pusan National University Institute for Research & Industry Cooperation; Noh Chang-ho; Yoon Ung-chan; Kwon O-hyeon; Choi Byeong-gi; (23 pag.)KR102046153; (2019); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem