In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2963-77-1 as follows. Recommanded Product: 4-(1H-Benzo[d]imidazol-2-yl)aniline
2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid (4-formyl-phenyl)-amide (0.1 mmol, 0.0284 g), 4-(1H-benzoimidazol-2-yl)-phenylamine (0.1 mmol, 0.021 g) and NaBH(OAc)3 (1.0 mmol, 0.211 g) were stirred in DMF (2 ml) at room temperature for 24 h. Then NaBH(OAc)3 (0.5 mmol, 0.11 g) was added to the reaction. The resulting mixture was stirred at room temperature for 36 h. Water (10 ml) was added to quench the reaction. Aq. K2CO3 solution (5 %) was added to neutralize the pH to ca. 7. The formed solid was filtered and washed with water (2 x 4 ml). The title compound was obtained as brown solid (0.042 g, 88 %). 1H NMR delta 4.33-4.30 (m, 6H), 6.72-6.69 (m, 3H), 6.97 (d, J= 8.1 Hz, 1H), 7.12-7.08 (m, 2H), 7.35 (d, J= 8.1 Hz, 2H), 7.55-7.40 (m, 4H), 7.71 (d, J= 8. 1 Hz, 2H), 7.87 (d, J= 8.1 Hz, 2H), 10.02 (s, 1H), 12.41 (br s, 1H). MS m/z = 477 (M+1)
According to the analysis of related databases, 2963-77-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IMCLONE SYSTEMS INCORPORATED; WO2005/42496; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem