Reference of 13750-62-4, A common heterocyclic compound, 13750-62-4, name is 1-Benzyl-2-methyl-1H-imidazole, molecular formula is C11H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 1-Benzyl-2-methylimidazole (0.32 cm3, ?2 mmol) was dissolved in acetonitrile (10 cm3) and then slowly added to warm solution of PdCl2 (0.18 g, 1 mmol) (in the synthesis of thiocyanate complex the NH4SCN (0.15 g, 2 mmol) was added) in acetonitrile (30 cm3). The mixture was refluxed for about 2 h and after the time the reaction solution was filtered and yellow single crystals were obtained by slow evaporation of the solvent. Yield: 88% for chloride complex (1) and 92% for thiocyanate analog (2).(0006)(1): IR (KBr): 3155 nuArH; 2927 nuCH; 1543 nuCN, 1497 nuC=C; 1454, 1351 delta(C-CH in the plane); 1274, 1155 delta(N-CH in the plane); 1067 delta(CH3); 750, 695 delta(Im ring).(0007)1H NMR (400 MHz, CDCl3) delta 7.43-7.26 (m, Ph), 7.17 (d, J = 1.8 Hz, Im), 7.13-7.06 (m, Ph), 6.74 (d, J = 1.8 Hz, Im), 5.03 (s, CH2), 2.92 (s, CH3).(0008)UV-Vis (acetonitrile, lambda (nm): 401.5, 276.1, 228.4, 211.5.
The synthetic route of 13750-62-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ma?ecki; Maro?; Polyhedron; vol. 50; 1; (2013); p. 452 – 460;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem