Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1072-62-4, name is 2-Ethyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Ethyl-1H-imidazole
General procedure: To a solution of (benzofuran-2-yl)(phenyl)methanol 4 (224 mg, 1 mmol) in dichloromethane (50 mL) was added methanesulfonyl chloride (1.2 mmol) and triethylamine (2 mmol) at 0 oC. The resulting mixture was stirred at room temperature for 12 h. After quenching the reaction with water (50 mL), the layers were separated. The organic phase was dried over anhydrous Na2SO4 and concentrated, and used for the next synthetic step. A mixture of the previous methanesulfonate and imidazole or substituted imidazole (3 mmol) was stirred in acetonitrile (20 ml) at reflux for 24-48 h (monitored by TLC). After cooling to room temperature, the solvent was concentrated, and the residue was diluted with EtOAc (20 mL). The organic layer was washed with water (20 mL) and brine (20 mL), dried over anhydrous Na2SO4 and concentrated. The residue was purified by column chromatography (silica gel, petroleum ether 60-90 oC : ethyl acetate = 3:1?1:1) to afford 6-9 in 60-75% yield (two steps) as yellow oil or powder.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Wang, Xue-Quan; Liu, Lan-Xiang; Li, Yan; Sun, Cheng-Jun; Chen, Wen; Li, Liang; Zhang, Hong-Bin; Yang, Xiao-Dong; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 111 – 121;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem