Synthetic Route of 3752-24-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3752-24-7, name is 4,5,6,7-Tetrahydro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 1 1-[4-(4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)phenyl]carboxaldehyde A mixture of 4,5,6,7-tetrahydro-1H-benzimidazole [25.6 g, 0.21 mol, prepared by following the procedure of H. Schubert and H. Fitsche, J. Prakt, Chem 4, (7), 407 (1958)], p-fluorobenzaldehyde (26 g, 0.21 mol) anhydrous K2 CO3 (29.2 g, 0.21 mol) and CuO (300 mg) in pyridine (100 ml) is heated under reflux for 18 hours. The reaction mixture is cooled, CH2 Cl2 is added and the solution is filtered. The inorganic residue is washed exhaustively with CH2 Cl2. The filtrate and the washings are combined and evaporated to dryness. The residue is dissolved in CH2 Cl2, filtered through silica gel and the filtrate is evaporated to give 15.5 g of the product, 1-[4-(4,5,6,7-tetrahydro-1H-benzimidazol-1-yl)phenyl]carboxaldehyde, mp 104-105 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5,6,7-Tetrahydro-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Warner-Lambert Company; US4717730; (1988); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem