Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36947-68-9, name is 2-Isopropyl-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H10N2
To 2-isopropylimidazole (28mg) in dry N,N-dimethylformamide (ImI) was added sodium hydride (lOmg, 60% dispersion in mineral oil). After 30 minutes, 2-chloro-6- (4-methanesulfonyl-piperazin-l-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, prepared via General Procedure B-3, was added and the reaction mixture was heated in the microwave for 45 minutes at 12O0C. The reaction mixture was diluted with ethyl acetate, washed with water, dried (MgSO4) and the solvent removed in vacuo and the residue purified using flash chromatography to yield 176. NMR (400MHz CDC13): 1.19(lH,s,CH), 1.30(6H,d(J=6.84), 2.61-2.63(4H,m,CH2), 2.74(3H,s,CH3), 3.23-3.25(4H,m,CH2), 3.79- 3.82(6H,m,CH2), 3.92-3.94(4H,m,CH2), 6.92(lH,s,ar), 7.18(lH,s,ar), 7.66(lH,d(J=1.49),ar). MH+ 506.30
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PIRAMED LIMITED; GENENTECH, INC.; BAYLISS, Tracy; CHUCKOWREE, Irina; FOLKES, Adrian; OXENFORD, Sally; WAN, Nan, Chi; CASTANEDO, Georgette; GOLDSMITH, Richard; GUNZNER, Janet; HEFFRON, Tim; MATHIEU, Simon; OLIVERO, Alan; STABEN, Steven; SUTHERLIN, Daniel, P.; ZHU, Bing-Yan; WO2008/70740; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem