Reference of 760212-58-6, A common heterocyclic compound, 760212-58-6, name is 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole, molecular formula is C19H13BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis Example 17: Synthesis of Compound A86 (0377) Pd(dba)3 (0.03 eq), (t-Bu)3P (0.06 eq), and toluene (based on a reagent (0.1 M 1 eq)) were added to a flask containing Int D-4 (1 eq) and R?-4 (1.2 eq) to form a mixed solution, and then, the mixed solution was stirred under reflux for 5 hours. After the reaction solution was cooled to room temperature, an extraction process was performed thereon using MC, followed by a washing process performed thereon using distilled water. Then, the resulting product obtained from the washing process was subjected to a drying process using MgSO4 and a vacuum distillation process. The residue obtained therefrom was purified by column chromatography, thereby completing the preparation of Compound A86 (yield: 75%). (0378) HRMS for C40H29N3[M]+: calculated: 551.69, found: 550. (0379) Elemental Analysis for C40H29N3 calculated: C, 87.08; H, 5.30; N, 7.62
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Samsung Display Co., Ltd.; Lee, Jungsub; (107 pag.)US2017/271596; (2017); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem