Related Products of 3012-80-4,Some common heterocyclic compound, 3012-80-4, name is 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde, molecular formula is C9H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 1.00 mmol of N-methyl-benzimidazole-2-carbaldehyde (0.1700 g) to a 15 mL capacity of polytetrafluoroethyleneIn the reaction kettle, after adding 10 mL of methanol to dissolve,Add 0.5 mmol of cobalt chloride tetrahydrate (0.119 g),Add 0.25 mmol under stirring2-Aminomethylpyridine (26 muL), stirring for 3 minutes, sealed, placed in an oven at 160 ° C for 48 h, then slowly cooled to obtain yellow block crystals (about 10 h down to room temperature), yield 46 percent (based on 2-aminomethylpyridine).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde, its application will become more common.
Reference:
Patent; Guangxi Normal University; Zeng Minghua; Zhu Zhonghong; (18 pag.)CN108164566; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem