A new synthetic route of

Adding a certain compound to certain chemical reactions, such as: 3034-38-6, name is 5-Nitro-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3034-38-6, SDS of cas: 3034-38-6

Preparative Example 23. A mixture of commercially available 4-nitroimidazole (5 g) and Pd/C (10wt%, 500 mg) in a premixed solution of acetyl chloride (4 mL) in MeOH (100 mL) was hydrogenated in a Parr shaker at 35 psi for 5 h. The mixture was filtered through celite and concentrated to give a black oil. [MH]+ = 115. This oil and methyl acetylpyruvate (6.4 g) were stirred in AcOH (7O mL) and MeOH (7O mL) at 65C for 18 h. The resulting mixture was absorbed on silica and purified by chromatography (silica, CH2Cl2/MeOH). Further purification of the resulting residue by chromatography (silica, EtOAc) afforded 2-methyl- imidazo[l,5-a]pyrimidine-4-carboxylic acid methyl ester as an orange solid (120 mg, 1.4%). [MH]+ = 192.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Nitro-1H-imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALANTOS PHARMACEUTICALS HOLDING, INC.; WO2008/63671; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem