Adding a certain compound to certain chemical reactions, such as: 33468-69-8, name is 4-(Trifluoromethyl)-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33468-69-8, SDS of cas: 33468-69-8
Example 5: Preparation of Compound 25A microwave vial was charged with Intermediate F (20 mg, 0.044 mmol), 4-(trifluoromethyl)- lH-imidazole (20 mg, 0.15 mmol), CS2CO3 (43.2 mg, 0.133 mmol) and DMA (500 mu). The mixture was heated at 150C under microwave irradiation for 3 h. The mixture was then purified by reverse-phase preparative HPLC (0: 100 to 95 :5 MeCN:water: 0.1% v/v TFA modifier) to afford 1-25 as the TFA salt. ‘H NMR (500 MHz, DMSO-d6) delta = 8.68-8.20 (m, 4H), 5.00 (s, 1H), 4.55-4.38 (m, 1H), 4.22-4.16 (m, 1H), 4.12 (q, 3=1 A, 2H), 3.35-3.24 (m, 1H), 3.22-3.01 (m, 2H), 2.33-2.21 (m, 1H), 2.21-2.09 (m, 1H), 1.30 (d, /=6.9, 5H), 1.24 (t, /=7.2, 3H). MS (EI) Calc’d for C20H24F3N10 [M+H]+, 461; found 461.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; MCGOWAN, Meredeth Ann; FONG, Kin Chiu; ANTHONY, Neville John; ZHOU, Hua; KATZ, Jason D.; YANG, Lihu; LI, Chaomin; TIAN, Yuan; MU, Changwei (Charles); YE, Baijun; SHI, Feng; ZHAO, Xiaoli; FU, Jianmin; WO2015/188369; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem