Some common heterocyclic compound, 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 4857-06-1
(5) 0.078 mol of 2-chlorobenzimidazole was dissolved in 90 mL of dry N,N-dimethylformamide, and 0.079 mol of 60% sodium hydrogen was added in portions in an ice bath and under a nitrogen atmosphere, followed by an ice bath. Stir for 30 minutes under nitrogen atmosphere, add 0.079 mol of 2-(trimethylsilyl)ethoxymethyl chloride, react at 20C for 16 hours, and turn the reaction solution into a yellow suspension, ice bathUnder cooling, 200 mL of water was slowly added, extracted with ethyl acetate, the organic phases were combined, and after drying, petroleum ether: ethyl acetate was used as eluent at a volume ratio of 10:1 to separate 16 g of white solid compound VII. The yield was 71.93%;
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4857-06-1, its application will become more common.
Reference:
Patent; Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.; He Xu; Hu Yongzhu; Zhang Chi; Liu Chun; Cui Xilin; (26 pag.)CN107663192; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem