Application of 693-98-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 693-98-1 name is 2-Methyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: In a typical experiment, imidazole (1.2 mmol), aryl halide (1.0 mmol), catalyst, and base (2.0 mmol) were added to a hydrothermal reactor (20 mL). The mixture was heated to the desired temperature with stirring. After the completion of the reaction and cooling to room temperature, the reaction mixture was diluted with water and extracted with ethyl acetate (3 × 15mL). The combined organic extracts were dried with anhydrous Na2SO4 and the obtained product was purified by column chromatography on silica gel using dichloromethane: methanol (100:1, v/v) as the eluent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methyl-1H-imidazole, and friends who are interested can also refer to it.
Reference:
Article; Huang, Qiang; Zhou, Limei; Jiang, Xiaohui; Qi, Xiaolong; Wang, Zhonghua; Lang, Wencheng; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 35; 11; (2014); p. 1818 – 1824;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem