Analyzing the synthesis route of C4H5ClN2O2S

According to the analysis of related databases, 137049-00-4, the application of this compound in the production field has become more and more popular.

Reference of 137049-00-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 137049-00-4 as follows.

Sodium hydride (33mg, 2eq) Soluble in 5mL anhydrous tetrahydrofuran, Compound Ib (190 mg, 1 eq) was added in portions with stirring. After stirring at room temperature for 30 minutes, Methylpyrazolesulfonyl chloride (157 mg, 1.3 eq) Dropped into the reaction solution, Stir at room temperature for 6 h, After the reaction is complete, Concentrate to tetrahydrofuran, Add 100mL of water, Adjust PH to nearly 7, Extracted with ethyl acetate three times, The organic layer was dried over anhydrous sodium sulfate and concentrated. The title compound 101 (219 mg, yield: 76%) was obtained.

According to the analysis of related databases, 137049-00-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jingkang; Ding Jian; Geng Meiyu; Xiong Bing; Ai Jing; Ma Yuchi; Dai Yang; (77 pag.)CN108570052; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem