Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10040-98-9, name is 4-Imidazol-1-yl-benzaldehyde, A new synthetic method of this compound is introduced below., Formula: C10H8N2O
A mixture of 4-(1H-imidazol-1-yl)benzaldehyde (0.025mol) and thiosemicarbazide (0.025 mol) in ethanol (40 mL)was refluxed for 12 h. The reaction mixture was cooled andfiltered. The product was crystallized from ethanol.M.p. 250.1 C.IR numax (cm-1): 3352.28 (N-H stretching), 3113.11 (AromaticC-H stretching), 2981.95 (Aliphatic C-H stretching), 1633.71,1608.63, 1533.41, 1517.98, 1473.62 (C=N, C=C stretchingand N-H bending), 1359.82 (C-H bending), 1300.02,1236.37, 1180.44, 1089.78, 1060.85 (C-N, C=S stretchingand aromatic C-H in plane bending), 960.55, 939.33, 914.26,835.18, 812.03, 767.67, 632.65, 617.22 (Aromatic C-H outof plane bending).1H NMR (400 MHz, DMSO-d6) delta (ppm): 7.11 (s, 1H),7.69 (d, J= 8.8 Hz, 2H), 7.82 (s, 1H), 7.93 (d, J= 8.4 Hz,2H), 8.05 (s, 1H), 8.09 (s, 1H), 8.24 (s, 1H), 8.34 (s, 1H,CH=N), 11.49 (s, 1H).MS (ESI) (m/z): (M+H)+ 246Anal. Calcd for C11H11N5S: C, 53.86; H, 4.52; N, 28.55.Found: C, 53.85; H, 4.54; N, 28.52.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Ciftci, Guel?en Akalin; Altintop, Mehlika Dilek; Temel, Halide Edip; Oezdemir, Ahmet; Kaplancikli, Zafer Asim; Letters in drug design and discovery; vol. 14; 5; (2017); p. 554 – 566;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem