Adding a certain compound to certain chemical reactions, such as: 66121-69-5, name is 1-Methyl-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 66121-69-5, Product Details of 66121-69-5
43.4 ml 1 .4M methylmagnesiumbromide in toluene were added dropwise to a mixture of 5.0 g 1 -methyl-1 H-imidazole-carbonitrile in 70 ml diethylether at 0C. After 30 min , the mixture was warmed up to ambient temperature. After 1 h the reaction was quenched with 1 M aqueous HCI solution and neutralised with saturated sodium bicarbonate solution. The reaction mixture was extracted with dichloromethane. The combined organic extracts were dried with magnesium sulfate and concentrated under reduced pressure. The crude material was purified by flash chromatography (dichloromethane/methanol = 98/2) to give the intermediate 3.3. Yield: 4.8 g of 3.3 (75% content; 62% of theory); Analysis: [M+H]+ = 125
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-imidazole-4-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; DOLLINGER, Horst; GNAMM, Christian; FIEGEN, Dennis; HOFFMANN, Matthias; LAMB, David, James; KLICIC, Jasna; SCHNAPP, Andreas; WO2013/156608; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem