Application of 15469-97-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15469-97-3, name is 1-Trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A. 2-Hydroxyethyl-N-triphenylmethylimidazole To a solution of N-triphenylmethylimidazole (15.5 g, 50 mmol) at 0°C in THF was added normal butyl lithium (nBuLi) (34.4 mL, 55 mmol) dropwise over 30 minutes. The mixture was stirred for 1 hour followed by gentle warming to 30°C over 30 minutes. The solution was cooled to 0°C, and ethylene oxide (24.4 mL, 50 mmol) was added to the mixture via a cannula. The mixture was stirred at 0°C for 2 hours and gradually warmed to ambient temperature over 16 hours. The solution was concentrated and the residue was chromatographed (flash silica, 19:1; chloroform:methanol) to yield 14.5g (82percent) of compound A as a white solid. MS (M+Na)+ 377+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Trityl-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; EP675112; (1995); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem