Synthetic Route of 930-62-1, These common heterocyclic compound, 930-62-1, name is 2,4-Dimethylimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A stirred solution of 3-(4-bromophenyl)-1 ,4-diazaspiro[4.4]non-3-en-2-one (D3) (770 mg2,4-dimethyl-1 H-imidazole (379 mg, 3.94 mmol) and copper bis(2,2,6,6-tetramethyl- 3,5-heptanedionate) (337 mg, 0.788 mmol) in DMF (3 ml) at room temperature, under argon was treated with potassium tert-butoxide (1179 mg, 10.51 mmol). After stirring at room temperature for 5 min, the mixture was heated to 12O0C and this temperature was maintained for 16 h. Further batches of the imidazole (379 mg) and copper bis(2, 2,6,6- tetramethyl-3,5-heptanedionate) (337 mg) were added and heating was continued for 7 days. The reaction mixture was cooled and diluted with saturated aqueous sodium bicarbonate solution (100 ml) and ethyl acetate (100 ml). After mixing, the mixture was filtered through Kieselghur. The ethyl acetate layer was separated and the aqueous phase re-extracted with ethyl acetate (50 ml). The combined organics were dried
The synthetic route of 930-62-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/34061; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem