Application of 50995-95-4, A common heterocyclic compound, 50995-95-4, name is 2-Propylimidazole, molecular formula is C6H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 1-L round-bottomed flask, 2-propylimidazole (15.0 g, 136 mmol) and I2 (110 g, 435mmol) were suspended in a mixture of CHCl3 (350 mL) and 2 M NaOH aqueous solution (350mL), and the mixture was stirred at room temperature of 45 h. To this mixture, a saturatedNa2S2O3 aqueous solution until the excess amount of I2 was quenched, the mixture was leftstand until the mixture separate to aqueous and CHCl3 layers. The CHCl3 layer was removedby using dropping funnel, then the aqueous layer was neutralized with acetic acid and asaturated NaHCO3 aqueous solution. The resulting precipitate was collected by filtration andwashed with water, then dried in vacuo at 60 C, to give 11 (43.7 g, 85%) as a soft yellowpowder;
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Murata, Tsuyoshi; Yamamoto, Yosuke; Yakiyama, Yumi; Nakasuji, Kazuhiro; Morita, Yasushi; Bulletin of the Chemical Society of Japan; vol. 86; 8; (2013); p. 927 – 939;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem