Adding a certain compound to certain chemical reactions, such as: 39513-26-3, name is 5-Bromo-1,3-dihydrobenzoimidazol-2-one, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39513-26-3, HPLC of Formula: C7H5BrN2O
Sodium hydride (60% in mineral oil, 256 mg, 6 4 mmol) was added to a solution of 5- Bromo-1 3-diotahydro-1 ,3-diotahydro-benzoiotarmdazol-2-one (427 mg, 2 mmol) in DMF (20 mL) at room temperature After 10 min, iodomethane (710 mg, 5 mmol) was added dropwise, and the resulting mixture was stirred at room temperature for overnight (15 hrs) The reaction was quenched with water (100 mL) and extracted with ethyl acetate (125 mL x 3) The combined extracts were washed with water (100 mL x2), saturated aqueous NaCI solution (100 mL), dried with MgSO4 After concentration, a pale yellow solid was obtained (539 mg) without further punfication
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1,3-dihydrobenzoimidazol-2-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; ADAMS, Christopher Michael; CHAMOIN, Sylvie; HU, Qi-Ying; ZHANG, Chun; WO2010/130794; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem