Adding a certain compound to certain chemical reactions, such as: 1546-79-8, name is 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1546-79-8, SDS of cas: 1546-79-8
The thymidine 3?-O-oxazaphospholidine derivative 7t (75.5 mg, 0.10 mmol) was dried by coevaporation with dry MeCN (3 mL) under Ar and dissolved in a 0.3 M solution of CMPT 8 (0.5 mL), which was dried over MS3A overnight. The resultant solution was added to the compound 6a (40.1 mg, 50 mumol), which was dried by coevaporation with dry MeCN prior to use, and the resultant mixture was stirred for 20 min at rt under Ar. N-(Trifluoroacetyl)imidazole (17.0 muL, 0.15 mmol) and i-Pr2NEt (44.0 muL, 0.25 mmol) were added and the mixture was stirred for 30 min at rt. Then DTD (31.9 mg, 0.15 mmol) was added and the mixture was stirred for 50 min at rt. The mixture was then concentrated under reduced pressure, and the residue was dissolved in dichloromethane (5.0 mL). A 6 vol% DCA solution in dichloromethane (5.0 mL) and Et3SiH (1.2 mL, 7.5 mmol) were added and the mixture was stirred for 20 min at rt. The mixture was washed with saturated NaHCO3 aqueous solutions (3 × 10 mL). The aqueous layers were combined and back-extracted with dichloromethane (2 × 10 mL). The organic layers were combined, dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by FSPE [1.6 cm column id, 4.8 g of fluorous silica gel, methanol-H2O 16 mL (80:20, v/v) then THF 25 mL] to give 13t (73.3 mg, colorless foam), which was analyzed by 31P NMR (121 MHz, CDCl3) delta 68.9.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Oka, Natsuhisa; Murakami, Ryosuke; Kondo, Tomoaki; Wada, Takeshi; Journal of Fluorine Chemistry; vol. 150; (2013); p. 85 – 91;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem