Application of 2849-93-6,Some common heterocyclic compound, 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, molecular formula is C8H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A suspension of the appropriate acid 17d-e (1 eq, 12.7 mmol) in EtOH (21 ml) was treated dropwise with SOCl2 (3 eq) under ice cooling, then heated to reflux over night. The solution was then concentrated in vacuum, treated with EtOH (3×20 mL) and n-hexane (3×20 mL)and dried under vacuum to give the pure title compound.
The synthetic route of 2849-93-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Giancotti, Gilda; Cancellieri, Michela; Balboni, Andrea; Giustiniano, Mariateresa; Novellino, Ettore; Delang, Leen; Neyts, Johan; Leyssen, Pieter; Brancale, Andrea; Bassetto, Marcella; European Journal of Medicinal Chemistry; vol. 149; (2018); p. 56 – 68;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem