Reference of 5465-29-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5465-29-2 name is 2-Propylbenzimidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
in 200 ml of water800 ml of concentrated sulfuric acid (i.e., 80% concentration), and 50.0 g of 2-propylbenzimidazole was added dropwise30% hydrogen peroxide 500ml, the reaction exothermic reflux, control the rate of dropping to keep the reaction solution has been boiling. After completion, the reaction was continued for 3 hours. Add water 1000ml, cold to room temperature. The solid was precipitated, and the mixture was stirred at 0 to 5 C for 3 hours, filtered, washed with water, and washed with 5% aqueous sodium sulfite solution (100 ml). The resulting solid column chromatography (eluent: water: methanol = 2: 1, ) Was imidazole-4,5-dicarboxylic acid 3 ยท lg, mp 267.3 C melting at the same time decomposition.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Propylbenzimidazole, and friends who are interested can also refer to it.
Reference:
Patent; Huanggang LUBAN Pharmaceutical Co.,Ltd. (LUBAN); YANG, XIAOLONG; LIU, XIANGQUN; LI, QIANG; CHEN, QIAN; YANG, TIEBO; (17 pag.)CN104262260; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem